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In the yeast Saccharomyces cerevisiae, the Zap1 transcriptional activator is a central player in this process. In response to zinc deficiency, Zap1 activates transcription of many genes and
The ability of Zap1 to activate transcription in zinc-limited cells is linked to the presence of multiple zinc-responsive domains within the Zap1 protein. Zap1 contains two independent activation domains (AD1
Biofilms of Candida albicans include both yeast cells and hyphae. Prior studies indicated that a zap1/ mutant, defective in zinc regulator Zap1, has increased accumulation of yeast cells in biofilms.
The zinc-responsive transcription activator Zap1 plays a central role in zinc homeostasis in the budding yeast Saccharomyces cerevisiae. In zinc-deficient cells, Zap1 binds to zinc responsive elements in
Zap1 is an activator protein that increases expression of 80 target genes in the yeast genome (Lyons et al., 2000; Wu et al., 2008). This protein has a DNA binding domain at its C-terminus and two
ZAP1 encodes a zinc-sensing transcription factor that regulates the cellular response to zinc deficiency. Under zinc depletion, Zap1p activates transcription of ~80 genes, and represses expression of a
In this study, we use a combined in vitro and in vivo analysis to map the DNA binding domain of Zap1 and determine which of its zinc fingers contrib-ute to ZRE recognition and binding.
The Zap1 transcription factor of Saccharomyces cerevisiae plays a central role in zinc homeostasis by controlling the expression of genes involved in zinc metabolism.